Sujets de thèse proposés pour le concours 2021 des contrats doctoraux de l'Université Lyon 1 et de l'INSA Lyon

(Sujets de thèse financés - Liste complète :  44 sujets)

CarMeN - UMR_S 1060 - Cardiovasculaire, Métabolisme, Diabétologie et Nutrition
1- Impact of immune checkpoint overexpression on obesity development, EL JAAFARI Assia
2- Study of the impact of FGF19 to prevent sarcopenia induced by chronic kidney disease, KOPPE Laetitia & VIDAL Hubert
3- Decipher the role of the pregnane X receptor (PXR) in the gut- liver axis, in particular in response to exposure to food pollutants (INT-TOX), LE MAGUERESSE Brigitte
4- Metabolic effects of lecithin mixed in different vegetable oils on inflammation and intestinal permeability linked to enterohepathic cycle, MICHALSKI Marie-Caroline, LAUGERETTE Fabienne & LETISSE Marion
5- Synergistic impact of food bioactives on postprandial metabolism and inflammation associated with gut health, NAZARE Julie-Anne & MICHALSKI Marie-Caroline
6- The cold receptor TRPM8, a new target against the aggravating effect of metabolic syndrome on reperfusion injury in a myocardial infarction model, BIDAUX Gabriel & GOURIOU Yves
7- Characterization of the acute inflammatory response of myocardial infarction in mice and patients by transcriptomics, BIDAUX Gabriel
8- Clinical and pre-clinical study of the alteration of the functional reticulum-mitochondria coupling in diabetic cardiomyopathy: the mitochondrial Ca2+ uniporter activation as a therapeutic strategy, PAILLARD Mélanie & THIBAULT Hélène
9- Non-invasive analysis of ER-mitochondria interactions in human peripheral blood mononuclear cells (PBMCs): nutritional regulations and alterations in type 2 diabetes, RIEUSSET Jennifer

LIBM - EA 7424 - Laboratoire Interuniversitaire de Biologie de la Motricité
10- Hypoxic signaling and neoangiogenesis in the failure of endovascular aneurysm repair, PIALOUX Vincent & MILLON Antoine
11- Effects of acute cardiovascular exercise and fatigue on physical motor learning and mental practice, DEBARNOT Ursula & LAPOLE Thomas
12- Characterization of muscle-tendon mechanical properties in sportswomen: effects of menstrual cycle and adaptations to exercise-induced muscle damage, MARTIN Cyril & FOURÉ Alexandre
13- Effects of different hypoxic trainings on hemoglobin mass, red blood cell senescence process and vascular responses, CONNES Philippe & ROBACH Paul

MMSB - UMR 5086 - Molecular Microbiology and Structural Biochemistry
14- Time-Resolved structural transitions of the Multidrug Transporter BmrA under turnover conditions, CHAPTAL Vincent
15- Molecular and cellular study of the serine/threonine-kinase StkP of Streptococcus pneumoniae, RAVAUD Stéphanie
16- Studying a new intracellular niche of Acinetobacter baumannii, SALCEDO Suzana
17- Structural characterization of bacterial effector proteins, TERRADOT Laurent

ICBMS - UMR 5246 - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
18- Selective Inhibitors of DYRK1A to treat neurodegenerative diseases, LOMBERGET Thierry & HALLÉ François
19- Targeting of tumors with tailor-made liposomes, GIRARD-EGROT Agnès & MANITI Ofelia
20- Development of 3D bioprinted respiratory epithelial tissue as relevant model for in-vitro respiratory infection studies, PETIOT Emma & MOREAU Karen
21- Exploration of the anti-inflammatory nucleotidase function of TNAP in atherosclerosis, MAGNE David & BESSUEILLE Laurence
22- Study of cellular biomechanical properties for the prediction of cell damage in regenerative medicine, MARQUETTE Christophe & COURTIAL Edwin-Joffrey

BioDyMIA - EA 3733 - Bioingénierie et Dynamique Microbienne aux Interfaces Alimentaires
23- Search for early markers of the biochemical degradation of animal origin foodstuffs during their shelf life, DEGRAEVE Pascal & ADT Isabelle

LAGEPP - UMR 5007 - Laboratoire d'Automatique, de Génie des Procédés et de Génie Pharmaceutique
24- New delivery approach targeting macrophages for active anti-tumor immunotherapy, BRIANÇON Stéphanie, THOMAS Eloïse & ALMOUAZEN Eyad
25- Bis(monoacylglycerol)phosphate, a putative regulator of Leishmania virulence towards macrophages, COSTAZ Céline & AZZOUZ-MAACHE Samira

CRCL - UMR 1052 - Centre de Recherche sur le Cancer de Lyon
26- Investigation of the pharmacological perturbation of the VDAC-1 ion channel involved in cancer and neurogenerative pathologies, KRIMM Isabelle & LE BORGNE Marc

UMRESTTE - UMR T9405 - Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement
27- Investigating the mediating and moderating role of specific factors in the relationship between noise levels and adverse health effects, LAFONT Sylvianne, EVRARD Anne-Sophie & LANOY Emilie

INMG - UMR 5310 - Institut NeuroMyoGène
28- Skeletal muscle resistance to cancer metastasis, MOUNIER Rémi & BELAIDI Elise

LaMCoS - UMR 5259 - Laboratoire de Mécanique des Contacts et des Structures
29- Study of the neuroprotective effects of a lipid of nutritional interest in Alzheimer's disease, BERNOUD-HUBAC Nathalie & LAZAR Adina Nicoleta

CREATIS - UMR 5220 - Centre de Recherche en Acquisition et Traitement d'Images pour la Santé
30- Preoperative high-resolution perfusion imaging of peritumoral edema in meningiomas as a biomarker of postoperative neurological functional outcome: Correlations with intraoperative optical imaging, COTTON François, MONTCEL Bruno & BERHOUMA Moncef
31- Optimal control Magnetic Resonance Elastography : a non-invasive tool to characterize liver elasticity in the case of hemochromatosis, BEUF Olivier & TSE VE KOON Kevin
32- Improving the clinical impact of multi-parametric MRI after acute myocardial infarction by unsupervised representation learning, VIALLON Magalie, DUCHATEAU Nicolas & CROISILLE Pierre
33- Ultrafast Ultrasound imaging to characterize the cardiovascular effect of immune therapy, COURAND Pierre-Yves & LIEBGOTT Hervé

RESHAPE - U1290 - Research on Healthcare Performance
34- Influence of health status and working conditions of healthcare professionals on patient outcomes : French national cohort in primary care, DUCLOS Antoine & VIPREY Marie
35- Development, evaluation and implementation of a patient-centred transition programme for stroke patients, combining case management and an Internet information platform, SCHOTT Anne-Marie & HAESEBAERT Julie

LabTAU - UMR 1032 - Laboratoire de thérapie et applications ultrasonores
36- Development of an extracorporeal treatment of breast and liver tumors using a toroidal HIFU transducer under ultrasound thermometry, MELODELIMA David
37- Ultrasound-Navigation-guided Interstitial Focused Ultrasound (FUS) for Conformal Therapy of Hepatocellular Carcinoma (HCC), N'DJIN W. Apoutou & MILOT Laurent

IP2I - UMR 5822 - Institut de Physique des 2 Infinis de Lyon
38- Crosstalk between UPR and ERAD pathways in Head and Neck Squamous Cell Carcinoma (HNSCC) : differential effect of X-Rays, protons and carbon ions irradiation under normoxic or hypoxic conditions, ARDAIL Dominique & WOZNY Anne-Sophie

LBTI - UMR 5305 - Laboratoire de Biologie Tissulaire et Ingénierie thérapeutique
39- New vessels development during skin wound healing : involvement of endoglin, BONOD Christelle
40- Sensitivity to severe side effects of radiotherapy: role of the cutaneous fibroblasts and transcriptional regulation, LAMARTINE Jérôme
41- Exploring the role of the extracellular matrix protein PCPE-2 in skin homeostasis and wound healing, MOALI Catherine
42- Bioactive injectable hydrogels for muscle formation, using controlled release of regulatory molecules, SOHIER Jérôme
43- Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology and Target Identification of Thiowurtzine, a Potent Inhibitor of the Opioid Receptors and the Ion Channels, TERREUX Raphaël
44- Development of a mRNA vaccine delivery system for induction of mucosal immune response against flu, MONGE Claire & ARRUDA Danielle